Drug induced diseases ppt

Ten percent of individuals worldwide are affected by autoimmune diseases, with systemic lupus erythematosus sle being one of the most common. Some drugs or therapeutic agents cause undesirable reactions in the lungs known as druginduced pulmonary diseases,which sometimes could be serious enough to cause. Factors that increase the risk of druginduced disease. Drug induced pulmonary disease is not a single disorder, but rather a common clinical problem in which a patient without previous pulmonary disease develops respiratory symptoms, chest xray changes, deterioration of pulmonary function, histologic changes, or several of these findings in association with drug therapy. A druginduced disease is defined as the unintended effect of a drug that results in mortality or morbidity with symptoms sufficient to prompt a. We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. Drug induced kidney diseases authorstream presentation. Ppt druginduced kidney disease powerpoint presentation. Nsaidcoxib induced hemodynamic renal failure nsaids causes hemodynamic acute renal failure due to inhibition of the synthesis of vasodilatory prostaglandins which are mainly contributing the vasodilation of afferent arterioles for normal maintenance of gfr cox2 inhibitors celecoxib and. A free powerpoint ppt presentation displayed as a flash slide show on id. She was not told that the drug was not approved by the fda for her condition. Find out about druginduced liver disease treatment, signs, and symptoms like itching, easy bruising, and jaundice, and learn how certain drugs can cause liver disease. Druginduced movement disorders are varied and can be caused by a number of medications that alter central nervous system neurochemistry d2 receptor blockade include. Druginduced lupus erythematosus dile is a variant of lupus erythematosus that resolves within days to months after withdrawal of the culprit drug in a patient with no underlying immune system dysfunction.

Yet the difference between a druginduced disease and an adverse drug reaction isnt as great. Therefore, the diagnosis is often diffi cult and, in most cases, is based on exclusion of all other possible causes. If there is too much medicine in your blood for your liver to. The manifestations of drug induced pulmonary diseases span the entire spectrum of pathophysiologic conditions of the respiratory tract. Drug induced pulmonary diseases linkedin slideshare. Epidemiological approaches to studying druginduced disease introduction current. Diseases caused by resistant staphylococci are being recognized, including septicemia and endocarditis. Diagnosis always consider a possible iatrogenic cause insistent questioning analgesic drugs, illicit drugs, psychoactive drugs, nsaids, overthecounter drugs, herbal remedies compatible chronology dih may sometimes appear 2 weeks after treatment is stopped fever, rash, eosinophilia immunoallergic mech. Druginduced hepatitis is a redness and swelling inflammation of the liver that is caused by a harmful toxic amount of certain medicines. A number of medications are known to cause undesirable reactions and lead to changes in the lungs or alter respiratory function. Drug induced hepatic injury accounts for more than 50 percent of cases of acute liver failure in the united states.

Despite best efforts to assure that all drugs are safe and effective, millions of patients each year develop druginduced diseases. Drug induced renal disease is common and responsible for a variety of pathological effects on the kidney, many of which are potentially recoverable. A druginduced disease is the unintended effect of a drug that results in mortality or morbidity with symptoms sufficient to prompt a patient to seek medical. From there, you can view and download your ashp ebooks to the reader of your choice. Druginduced disease definition of druginduced disease. Despite best efforts to assure that all drugs are safe and effective, millions of patients each year develop drug induced diseases. The manifestations of druginduced pulmonary diseases span the entire spectrum of pathophysiologic conditions of the respiratory tract. The adrs are defined and categorized as per the definition of edwards and aronson, as any response to a drug that is noxious, undesireable and unintended and. Druginduced liver disease comes in many types, and has many potential causes. Also know which drugs can cause parkinsonism and how to differentiate between drug induced parkinsonism and parkinsonism disease.

As with most drug induced diseases, the pathological changes are nonspecifi c. Druginduced myopathy ranges from mild myalgias with or without mild weakness to chronic myopathy with severe weakness and to massive rhabdomyolysis with acute renal failure. Druginduced liver disease, 3 rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Oct 23, 2012 a wide variety of drugs may be associated with serious cardiovascular toxicity. Drugs can cause acute renal injury, intrarenal obstruction, interstitial nephritis, nephrotic syndrome, and acidbase and fluid electrolytes disorders. Sep 01, 2015 drug induced nephrotoxicity are more common among infants and young children and in certain clinical situations such as underlying renal dysfunction and cardiovascular disease.

Druginduced pulmonary disease is not a single disorder, but rather a common clinical problem in which a patient without previous pulmonary disease develops respiratory symptoms, chest xray changes, deterioration of pulmonary function, histologic changes, or several of these findings in. Druginduced liver disease can have many different clinical presentations. Know the characteristics, epidemiology, treatment, diagnosis of druginduced parkinsonism. Drug induced kidney disease is best prevented by avoiding the use of potentially. Druginduced acute renal dysfunction karen shalansky, pharm. The initial diagnosis of druginduced kidney disease dikd typically involves detection of elevated serum creatinine s cr and blood urea nitrogen, for which there is a temporal relationship between the toxicity and use of a potentially nephrotoxic drug. Two patients of the same age, gender and weight, and in similar health, can take the same medication at the same dose for the same amount of time. Clinicians should prescribe a relatively limited panel of drugs. Prevention, detection, and management is a well organised, easy to use reference source that fills a sizeable gap in the available literature. The initial diagnosis of drug induced kidney disease dikd typically involves detection of elevated serum creatinine s cr and blood urea nitrogen, for which there is a temporal relationship between the toxicity and use of a potentially nephrotoxic drug. Some drug induced lung diseases, such as pulmonary fibrosis, may never go away and can worsen, even after the medicine or substance is stopped and can lead to severe lung disease and death. Druginduced kidney disease is best prevented by avoiding the use of potentially.

Specific examples of patients with drug induced diseases. Depending on their severity, druginduced diseases may be classified as mild, moderate, severe, or lethal if they cause death. Drug induced pulmonary diseases 1 bronchospasm, wheezing and cough 2 pulmonary edema 3 pulmonary hypertension 4 interstitial lung disease interstitial pneumoniainfiltrates pulmonary fibrosis 4. Drug induced liver injury dili professor kassim alsaudi m. In approximately 75% of these cases, liver transplantation is ultimately required for patient survival. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the. Druginduced diseases refer to those adverse effects of drugs that are serious enough for the patient to consult a doctor or get hospitalized. Some druginduced lung diseases, such as pulmonary fibrosis, may never go away and can worsen, even after the medicine. Drug induced pulmonary disease is defined as any lung disease caused by a drug or medication 3. Druginduced pulmonary disease is lung disease brought on by a bad reaction to a medicine. This rare adverse effect occurs in approximately 15,000 to 30,000 individuals per year in the united states. Miller medical 2010 1110 according to the authors, a druginduced disease as an unintended effect of a drug, which results in mortality or morbidity with symptoms sufficient to prompt a patient to seek medical attention andor require. Drug induced diseases did also called as iatrogenic diseases, are well known but least studied entity. Druginduced diseases focus of pharmacy manual managed care.

For others, particularly with opioids, drug addiction begins with exposure to prescribed medications, or receiving medications from a friend or relative who has been prescribed the medication. Sign in with your ashp username and password to access purchased ebooks in my library. As with most druginduced diseases, the pathological changes are nonspecifi c. Different classes of drugs, by virtue of immunological mechanisms or direct toxicity initiate certain stereotyped renal responses. Despite best efforts to ensure the safety and effectiveness of all drugs, millions of patients each year develop druginduced diseases. The form of parkinsonism that develops after being treated with particular medications is known as druginduced parkinsonism. Anticonvulsant druginduced liver injury virtually all of the major antiepileptic drugs can cause hepatotoxicity, although a fatal outcome is rare.

Since the publication of the first edition of this book in 2005, numerous drugs have been withdrawn from the market in the united states because of morbidity andor mortality associated with druginduced disease. Druginduced diseases can affect various organ systems of the body. One may develop a drug induced disease, while the other only experiences positive effects. Druginduced renal disease is common and responsible for a variety of pathological effects on the kidney, many of which are potentially recoverable. The main types of renal injury predominantly involve the tubules and interstitium, leading to acute tubular injury and necrosis, or interstitial nephritis with inflammatory tubular injury. Drug induced myopathy ranges from mild myalgias with or without mild weakness to chronic myopathy with severe weakness and to massive rhabdomyolysis with acute renal failure. Druginduced nephrotoxicity are more common among infants and young children and in certain clinical situations such as underlying renal dysfunction and cardiovascular disease. Abstract and introduction acute druginduced skin disorders chronic druginduced skin disorders conclusion references warfarin tissue necrosis is a. Laboratory indices in the diagnostics of kidney diseases laboratory indices in the diagnostics of kidney diseases marushchak maria definition examination of urine by chemical, physical. Depression sheila botts and melody ryan depression is one of the most common psychiatric illnesses, and it may interfere significantly with a patients daily functioning and quality of life. Prevention, detection, and management, second edition will help pharmacists, physicians, nurses, and other health care professional on the front lines of patient care and pharmacotherapy to expect the unexpected and to be more knowledgeable about the risk of drug induced diseases. Renal injury is common in apap still the largest cause of death from alf in us overall summary. Druginduced kidney disease free download as powerpoint presentation.

Jul 23, 2019 the form of parkinsonism that develops after being treated with particular medications is known as drug induced parkinsonism. It gives american society of healthsystem pharmacists 7272 wisconsin avenue bethesda, md 20814 this vital subject the comprehensive coverage that it deserves. Some drugs or therapeutic agents cause undesirable reactions in the lungs known as drug induced pulmonary diseases,which sometimes could be serious enough to cause. Since the first edition of this book was published in 2005, numerous drugs have been withdrawn from the market in the united states as a result of morbidity andor mortality associated with druginduced diseases. Druginduced pulmonary disease msd manual professional edition. A wide variety of drugs may be associated with serious cardiovascular toxicity. Over 150 agents have been associated with rhabdomyolysis. Druginduced pulmonary diseases types, symptoms and treatment. Druginduced pulmonary disease pulmonary disorders msd. Druginduced pulmonary diseases types, symptoms and. These reactions are known as druginduced pulmonary diseases. Dili and apap 2014 identifying druginduced hepatotoxicity is vital bad outcomes can and do occur. Prevention, detection, and management, second edition will help pharmacists, physicians, nurses, and other health care professional on the front lines of patient care and pharmacotherapy to expect the unexpected and to be more knowledgeable about.

D importance prognosis may be worse than for viral hepatitis responsible for 3% to 10% of all. Druginduced hepatic injury accounts for more than 50 percent of cases of acute liver failure in the united states. Iatrogenic disease or drug induced disease did is an ever enduring concern for patients, healthcare professionals and health administrators. The kidney maintains the vital functions of clearing excess body fluid and removing metabolic and exogenous toxins from the blood the kidney is particularly.

In the past these reactions and drug induced illnesses were blamed on impurities, overdosage, or individual sensitivity. Know the characteristics, epidemiology, treatment, diagnosis of drug induced parkinsonism. Druginduced diseases did also called as iatrogenic diseases, are well known but least studied entity. Drug induced liver disease, 3 rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Druginduced liver injury dili represents a diverse set of responses following exposure to any manufactured or naturally occurring chemical compound. Since the first edition of this book was published in 2005, numerous drugs have been withdrawn from the market in the united states as a result of morbidity andor mortality associated with drug induced diseases. Frequent psych issues and drug abuse in both groups multiple products important in at least 20%, more in pain patients. What is druginduced parkinsonism, know its characteristics. Some of the risk factors of dids are multiple chronic diseases, multiple physicians, hospitalization, medical or surgical procedures, long duration of medicine use, advancing age, female sex and a particular class of drugs 6,7,8.

Dile can arise months to years after exposure to drugs prescribed to treat various medical conditions eg, antihypertensives, antibiotic. Additional urine tests protein excretion, creatinine concentration, osmolality, or sodium excretion. Liz, a 54year old woman, was prescribed the heart drug amiodarone cordarone to treat a common heart condition. Druginduced renal disease can mimic renal disease from other causes, such as autoimmune disease and infection.

Mar 03, 20 anticonvulsant druginduced liver injury virtually all of the major antiepileptic drugs can cause hepatotoxicity, although a fatal outcome is rare. Drug induced pulmonary diseases by vishwanath gouda 1st year m. More than 75 percent of idiosyncratic drug reactions result in liver transplantat. The liver helps to break down certain medicines in your blood. Pharmacotherapeutic specialist, vgh clinical professor, ubc apr 8, 2010 outline pseudo renal failure acute renal failure prerenal nsaids, cyatacrolimus, aceiarb, diuretics intrinsic atn vs ain atn aminoglycosides, amphotericin b, radiocontrast media. Pathogenesis, diagnosis, and acute liver failure the postgraduate course at this years meeting of the american association for the study of liver diseases aasld. Druginduced kidney disease constitutes an important cause of acute renal failure and chronic kidney disease in present day clinical practice. Ulceration and perforation along the gastrointestinal tract follow steroid medication. Druginduced disease definition of druginduced disease by. Although the precise incidence is unknown, druginduced myopathy is among the most common causes of muscle disease. Several drugs have been banned because of their ability to cause serious diseases.

Nsaidcoxib induced hemodynamic renal failure nsaids causes hemodynamic acute renal failure due to inhibition of the synthesis of vasodilatory prostaglandins which are mainly contributing the vasodilation of afferent arterioles for normal maintenance of gfr cox2. Yet the difference between a drug induced disease and an adverse drug reaction isnt as great. Drug induced acute renal dysfunction karen shalansky, pharm. The muneaki tajiri foundation will confer the award on the south korean foundation for its efforts to assist people suffering carbon disulfide poisoning caused by a rayon factory near seoul, and on taiho pharmaceutical co. Druginduced liver injury is of major concern owing to the ever increasing number of compounds introduced into the market for treatment of various diseases as well as the. Prevention, detection, and management article pdf available in american journal of pharmaceutical education 706 december 2006 with 3,279 reads how we measure reads. Nephrolithiasis formation of renal calculi or kidney stones occurs as the result of abnormal crystal precipitation in the renal collecting system intratubular precipitation of crystallinematerial prevalence of drug induced nephrolithiasis is 1% signs and symptoms pain, haematuria, infection, or, occasionally, urinary tract obstruction with kidney injury. Drug addiction can start with experimental use of a recreational drug in social situations, and, for some people, the drug use becomes more frequent. Pharmacotherapeutic specialist, vgh clinical professor, ubc apr 8, 2010 outline pseudo renal failure acute renal failure. Drugs considered lupus inducing vary in pharmacologic. Druginduced kidney diseases np singh, a ganguli, a prakash abstract druginduced kidney disease constitutes an important cause of acute renal failure and chronic kidney disease in present day clinical practice. Drug induced kidney disease free download as powerpoint presentation. Drug addiction substance use disorder symptoms and causes. In an attempt to help practitioners and plans gather and to disseminate information about druginduced diseases defined as adverse medical.

Toxicity due to drugs primarily used for treating cardiac disorders is the most extensively documented, especially the arrhythmias due to digitalis glycosides. Mar 01, 2018 factors that increase the risk of drug induced disease. It may only be detected through awareness of the possibility, suspicion, careful history, exclusion of other likely causes. What you need to know about druginduced disease medshadow. Druginduced liver disease accounts for as much as 20% of acute liver failure in pediatric populations and a similar percentage of adults with acute liver failure. Druginduced lupus erythematosus clinical presentation. The last thing one would expect is that the medication used to relieve discomfort would actually. Although the precise incidence is unknown, drug induced myopathy is among the most common causes of muscle disease. A thorough physical examination and medical history should be performed. Thank you for your interest in spreading the word about the bmj. In the past these reactions and druginduced illnesses were blamed on impurities, overdosage, or individual sensitivity.

Various arrhythmias are also caused by toxic levels of many antiarrhythmic agents including quinidine, procainamide and phenytoin. Apr 05, 2020 abstract and introduction acute drug induced skin disorders chronic drug induced skin disorders conclusion references warfarin tissue necrosis is a rare but serious disorder that may occur 3 to 5. Pathogenesis, diagnosis, and acute liver failure the postgraduate course at this years meeting of the american association for the study of. An experience of a tertiary care teaching hospital from india.